Hippocampal functional connectivity across age in an <i>App</i> knock-in mouse model of Alzheimer's disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a progressive neurodegenerative disease. The early processes of AD, however, are not fully understood and likely begin years before symptoms manifest. Importantly, disruption of the default mode network, including the hippocampus, has been implicated in AD.

Methods

To examine the role of functional network connectivity changes in the early stages of AD, we performed resting-state functional magnetic resonance imaging (rs-fMRI) using a mouse model harboring three familial AD mutations (App ^{NL-G-F/NL-G-F} knock-in, APPKI) in female mice in early, middle, and late age groups. The interhemispheric and intrahemispheric functional connectivity (FC) of the hippocampus was modeled across age.

Results

We observed

SUBMITTER: Morrissey ZD 

PROVIDER: S-EPMC9878347 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature