Association of Lipid-Lowering Drugs With Risk of Psoriasis: A Mendelian Randomization Study.

ABSTRACT:

Importance

Lipid pathways have been implicated in the pathogenesis of psoriasis, and some lipid-lowering drugs, such as statins, are hypothesized to have disease-modifying properties. However, large population-level studies are scarce, and causal interpretation of results from traditional observational designs is limited by confounding.

Objective

To investigate the causal association between genetically proxied lipid-lowering drugs and psoriasis risk.

Design, setting, and participants

This 2-sample mendelian randomization study was performed from August to October 2022 and included population-level genome-wide association studies of psoriasis in the UK Biobank and FinnGen studies and low-density lipoprotein (LDL) by the Global Lipids Genetics Consortium. The inverse v

SUBMITTER: Zhao SS 

PROVIDER: S-EPMC9878432 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature