Differential expression profiles and functional prediction of circRNA in mice with traumatic heterotopic ossification.

ABSTRACT:

Background

Traumatic heterotopic ossification (HO) is an intractable sequela incited by inflammatory insult. To date, the exact molecular mechanisms of traumatic HO formation remain unclear. Recent studies have indicated that circular RNAs (circRNAs) participate in various human skeletal diseases. Although the formation of HO recapitulates many programs during bone development and remodeling, few data are available concerning whether circRNAs could participate in this pathological osteogenesis.

Methods

To investigate the differentially expressed circRNAs (DE-circRNAs) in HO formation, microarray assay was performed to analyze the circRNA expression profile in four pairs of mice HO tissues and normal tissues. Then, qRT-PCR was applied to verify the microarray data. Gene Ontol

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9878564 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature