Susceptibility identification for seasonal influenza A/H3N2 based on baseline blood transcriptome.

ABSTRACT:

Introduction

Influenza susceptibility difference is a widely existing trait that has great practical significance for the accurate prevention and control of influenza.

Methods

Here, we focused on the human susceptibility to the seasonal influenza A/H3N2 of healthy adults at baseline level. Whole blood expression data for influenza A/H3N2 susceptibility from GEO were collected firstly (30 symptomatic and 19 asymptomatic). Then to explore the differences at baseline, a suite of systems biology approaches - the differential expression analysis, co-expression network analysis, and immune cell frequencies analysis were utilized.

Results

We found the baseline condition, especially immune condition between symptomatic and asymptomatic, was different. Co-expression module tha

SUBMITTER: Tang J 

PROVIDER: S-EPMC9878565 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature