Development and validation of brain-derived neurotrophic factor measurement in human urine samples as a non-invasive effect biomarker.

ABSTRACT:

Background

Brain-derived neurotrophic factor (BDNF), a neurotrophic growth factor mainly expressed in the brain, has been proposed as a potential effect biomarker; that is, as a measurable biomarker whose values could be associated with several diseases, including neurological impairments. The European Human Biomonitoring Initiative (HBM4EU) has also recognized effect biomarkers as a useful tool for establishing link between exposure to environmental pollutants and human health. Despite the well-establish protocol for measuring serum BDNF, there is a need to validate its assessment in urine, a non-invasive sample that can be easily repeated over time. The aim of this study was to develop, standardize and validate a methodology to quantify BDNF protein levels in urine samples before

SUBMITTER: Olivas-Martinez A 

PROVIDER: S-EPMC9878568 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature