Limited evidence for sympathetic neural overactivation in older patients with type 2 diabetes mellitus.

ABSTRACT:

Introduction

Mechanistic studies suggested that excess sympathetic activity promotes arterial hypertension while worsening insulin sensitivity. Older patients with type 2 diabetes are at particularly high cardiovascular and metabolic risk. However, data on sympathetic activity in this population is scarce.

Methods

We studied 61 patients with type 2 diabetes mellitus (22 women, 60.9 ± 1.4 years; 39 men, 60.9 ± 1.4 years). They had to have diabetes for at least 2 years, a hemoglobin A1c of 6.5-10%, a body-mass-index of 20-40 kg/m², and had to be treated with stable doses of metformin only. We recorded ECG, finger and brachial blood pressure, and muscle sympathetic nerve activity (MSNA).

Results

MSNA was 37.5 ± 2.5 bursts/min in women and 39.0 ± 2.0 bursts/min

SUBMITTER: Heusser K 

PROVIDER: S-EPMC9878600 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature