An Update on Non-invasive Approaches for Genetic Testing of the Preimplantation Embryo.

ABSTRACT: Preimplantation Genetic Testing (PGT) aims to reduce the chance of an affected pregnancy or improve success in an assisted reproduction cycle. Since the first established pregnancies in 1990, methodological approaches have greatly evolved, combined with significant advances in the embryological laboratory. The application of preimplantation testing has expanded, while the accuracy and reliability of monogenic and chromosomal analysis have improved. The procedure traditionally employs an invasive approach to assess the nucleic acid content of embryos. All biopsy procedures require high technical skill, and costly equipment, and may impact both the accuracy of genetic testing and embryo viability. To overcome these limitations, many researchers have focused on the analysis of cell-free DNA (

SUBMITTER: Kakourou G 

PROVIDER: S-EPMC9878856 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature