Mapping the methodological diversity of published drug discontinuation studies-a scoping review of study topics, objectives, and designs.

ABSTRACT:

Background

Trials evaluating drug discontinuation (drug discontinuation trials, DDTs) show a broad methodological spectrum. There are several specific methodological aspects in drug discontinuation trials (e.g., determination of research question; configuration of intervention; definition of outcomes). To verify this specifies, we did a scoping review about the study designs of drug discontinuation trials.

Methods

A systematic literature search in Medline (PubMed), The Cochrane Library, EMBASE, CINAHL, Web of Science, and PsycINFO was performed. In a two-step selection process, we identified DDTs, which evaluate the discontinuation of one or more long-term medication as the investigated intervention, by two independent reviewers. Besides bibliographic data, we extracted seve

SUBMITTER: Grede N 

PROVIDER: S-EPMC9878942 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature