Impacts of sodium butyrate on intestinal mucosal barrier and intestinal microbial community in a weaned piglet model.

ABSTRACT:

Objective

Butyrate is thought to enhance intestinal mucosal homeostasis, but the detailed mechanism remains unclear. Therefore, further investigation on the mechanism of butyrate regulation of intestinal mucosal homeostasis was performed.

Materials and methods

This study used weaned piglets with similar intestinal metabolic function to humans as a research model. The dietary supplemented 0.2% sodium butyrate group (0.2% S) and negative control group (CON) were established to detect the effects of butyrate on growth performance, intestinal tissue morphology, mucosal barrier function, and intestinal microbial community structure in weaned piglets.

Results

There was an increase in average daily gain (ADG) during three different experimental periods and a reduction in ave

SUBMITTER: Liu H 

PROVIDER: S-EPMC9879053 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature