Diversity of σ⁶⁶-Specific Promoters Contributes to Regulation of Developmental Gene Expression in Chlamydia trachomatis.

ABSTRACT: Promoter recognition by the RNA polymerase (RNAP) holoenzyme is a key step in gene regulation. In Chlamydia trachomatis, a medically important obligate intracellular bacterium, σ⁶⁶ allows the RNAP to initiate promoter-specific transcription throughout the chlamydial developmental cycle. Here, we investigated the intrinsic properties of σ⁶⁶-specific promoters with emphasis on their role in the developmental gene expression of C. trachomatis. First, we examined whether promoters that contain a 5'-T(-15)G(-14)-3' (TG) motif upstream from the -10 element appear more often than others in genes that are preferentially expressed during the early, middle, or late stages of the C. trachomatis developmental cycle. We then determined the critical genetic elements that are requir

SUBMITTER: Shen L 

PROVIDER: S-EPMC9879106 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature