Dauer fate in a <i>Caenorhabditis elegans</i> Boolean network model.

ABSTRACT: Cellular fates are determined by genes interacting across large, complex biological networks. A critical question is how to identify causal relationships spanning distinct signaling pathways and underlying organismal phenotypes. Here, we address this question by constructing a Boolean model of a well-studied developmental network and analyzing information flows through the system. Depending on environmental signals Caenorhabditis elegans develop normally to sexual maturity or enter a reproductively delayed, developmentally quiescent 'dauer' state, progressing to maturity when the environment changes. The developmental network that starts with environmental signal and ends in the dauer/no dauer fate involves genes across 4 signaling pathways including cyclic GMP, Insulin/IGF-1, TGF-<

SUBMITTER: Kandoor A 

PROVIDER: S-EPMC9879150 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature