Urine-based multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS), a life-threatening condition during critical illness, is a common complication of COVID-19. It can originate from various disease etiologies, including severe infections, major injury, or inhalation of irritants. ARDS poses substantial clinical challenges due to a lack of etiology-specific therapies, multisystem involvement, and heterogeneous, poor patient outcomes. A molecular comparison of ARDS groups holds the potential to reveal common and distinct mechanisms underlying ARDS pathogenesis.

Methods

We performed a comparative analysis of urine-based metabolomics and proteomics profiles from COVID-19 ARDS patients (n = 42) and bacterial sepsis-induced ARDS patients (n = 17). To this end, we used two different approaches,

SUBMITTER: Batra R 

PROVIDER: S-EPMC9879238 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature