Melatonin integrates multidimensional regulation of Na⁺/K⁺-ATPase in ionocytes and promotes stress and ease response in hypoxia-induced air-breathing fish: lessons from integrative approach.

ABSTRACT: As circadian regulator, melatonin is involved in many physiological processes including ionosmotic regulation in fishes. Na⁺/K⁺-ATPase (NKA), an ubiquitous Na⁺/K⁺ transporter in ionocyte epithelia that drives electrochemical Na⁺ gradients and systemic osmotic integration, is a target of stress in fish. However, it is not certain how melatonin regulates NKA functions in ionocyte epithelia and how it modulates the adaptive response such as stress and ease response in fish particularly in hypoxia condition. We, thus, examined the short-term in vivo action of melatonin on the dynamics of NKA regulation in branchial, renal and intestinal ionocytes of hypoxia-induced air-breathing fish (Anabas testudineus Bloch). Interestingly,

SUBMITTER: Peter MCS 

PROVIDER: S-EPMC9879292 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature