Circulating tumour cells in patients with lung cancer universally indicate poor prognosis.

ABSTRACT:

Background

In lung cancer, the relevance of various circulating tumour cell (CTC) subgroups in different lung cancer subtypes is unclear. We performed a comprehensive meta-analysis to assess the prognostic value of CTCs in the different histological types of lung cancer, with particular respect to CTC subtypes, cut-offs and time points of CTC enumeration.

Methods

We searched MEDLINE, Web of Science and Embase alongside relevant studies evaluating the prognostic value of CTCs in lung cancer patients. A random-effects model was used for meta-analysis, calculating hazard ratios (HRs), 95% confidence intervals and p-values.

Results

27 studies enrolling 2957 patients were included. CTC detection indicates poor prognosis, especially in small cell lung cancer (SCLC) patients

SUBMITTER: Jin F 

PROVIDER: S-EPMC9879327 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature