Aflatoxin B₁ exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-mediated manner.

ABSTRACT: Aflatoxin B₁ (AFB₁) contamination in food and feed leads to severe global health problems. Acting as the frontier immunological barrier, the intestinal mucosa is constantly challenged by exposure to foodborne toxins such as AFB₁ via contaminated diets, but the detailed toxic mechanism and endogenous regulators of AFB₁ toxicity are still unclear. Here, we showed that AFB₁ disrupted intestinal immune function by suppressing macrophages, especially M2 macrophages, and antimicrobial peptide-secreting Paneth cells. Using an oxylipinomics approach, we identified that AFB₁ immunotoxicity is associated with decreased epoxy fatty acids, notably epoxyeicosatrienoic acids, and increased soluble epoxide hydrolase (sEH) levels in the int

SUBMITTER: Wang W 

PROVIDER: S-EPMC9879385 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature