Increased intestinal-fatty acid binding protein in obesity-associated type 2 diabetes mellitus.

ABSTRACT:

Background

Obesity is a traditional risk factor for type 2 diabetes mellitus (T2DM). However, recent studies reported that metabolically unhealthy obesity (MUO) exerts a higher risk of developing T2DM than metabolically healthy obesity (MHO) because of its higher state of insulin resistance. This may happen due to metabolic endotoxemia through gut dysbiosis and increased intestinal permeability. Our study aimed to know the association of intestinal permeability using intestinal fatty acid-binding protein (I-FABP) with obesity-related T2DM patients in Indonesia.

Methods

This was a cross-sectional study that recruited 63 participants with obesity defined using body mass index (BMI) classification for the Asia-Pacific population (BMI ≥25 kg/m2). All participants were then group

SUBMITTER: Tahapary DL 

PROVIDER: S-EPMC9879407 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature