Safety Review and Perspectives of Transcranial Focused Ultrasound Brain Stimulation.

ABSTRACT: Ultrasound is an important theragnostic modality in modern medicine. Technical advancement of both acoustic focusing and transcranial delivery have enabled administration of ultrasound waves to localized brain areas with few millimeters of spatial specificity and penetration depth sufficient to reach the thalamus. Transcranial focused ultrasound (tFUS) given at a low acoustic intensity has been shown to increase or suppress the excitability of region-specific brain areas. The neuromodulatory effects can outlast the sonication, suggesting the possibility of inducing neural plasticity needed for neurorehabilitation. Increasing numbers of studies have shown the efficacy and excellent safety profile of the technique, yet comparisons among the safety-related parameters have not been compiled. T

SUBMITTER: Lee W 

PROVIDER: S-EPMC9879416 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature