A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks.

ABSTRACT: In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory networks so that the expression of core genes (partial system) is insensitive to environmental changes. Then, we found the expression levels of the remaining genes autonomously increase to provide a plastic (sensitive) response. A feedforward structure from the non-core to core genes evolved autonomously. Negative proportionality was observed between the average changes in core and non-core genes, reflecting reciprocity between the macroscopic robustness of homeostatic genes and plasticity of regulator genes. The proportion coefficient between those genes is represented by their number ratio, as in the "lever princ

SUBMITTER: Hatakeyama TS 

PROVIDER: S-EPMC9879506 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature