Transcriptional responses define dysregulated immune activation in Hepatitis C (HCV)-naive recipients of HCV-infected donor kidneys.

ABSTRACT: Renal transplantation from hepatitis C (HCV) nucleic acid amplification test-positive (NAAT-positive) donors to uninfected recipients has greatly increased the organ donation pool. However, there is concern for adverse outcomes in these recipients due to dysregulated immunologic activation secondary to active inflammation from acute viremia at the time of transplantation. This includes increased rates of cytomegalovirus (CMV) DNAemia and allograft rejection. In this study, we evaluate transcriptional responses in circulating leukocytes to define the character, timing, and resolution of this immune dysregulation and assess for biomarkers of adverse outcomes in transplant patients. We enrolled 67 renal transplant recipients (30 controls, 37 HCV recipients) and performed RNA sequencing on ser

SUBMITTER: Steinbrink JM 

PROVIDER: S-EPMC9879532 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature