Acid-sensing ion channel 1a in the central nucleus of the amygdala regulates anxiety-like behaviors in a mouse model of acute pain.

ABSTRACT: Pain is commonly comorbid with anxiety; however, the neural and molecular mechanisms underlying the comorbid anxiety symptoms in pain (CASP) have not been fully elucidated. In this study, we explored the role of acid-sensing ion channel 1a (ASIC1a), located in GABAergic neurons from the central nucleus of the amygdala (GABA^CeA), in the regulation of CASP in an acute pain mouse model. We found that the mice displayed significant mechanical pain sensitization and anxiety-like behaviors one day post injection of complete Freud's adjuvant (CFA1D). Electrophysiological recordings from acute brain slices showed that the activity of GABA^CeA neurons increased in the CFA1D mice compared with that in the saline mice. In addition, chemogenetic inhibition of GABA^CeA ne

SUBMITTER: Shi P 

PROVIDER: S-EPMC9879607 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature