A cross-validation based approach for estimating specific gravity in elementary-school aged children using a nonlinear model.

ABSTRACT: Environmental research often relies on urinary biomarkers which require dilution correction to accurately measure exposures. Specific gravity (SG) and creatinine (UCr) are commonly measured urinary dilution factors. Epidemiologic studies may assess only one of these measures, making it difficult to pool studies that may otherwise be able to be combined. Participants from the National Health and Nutrition Examination Survey 2007-2008 cycle were used to perform k-fold validation of a nonlinear model estimating SG from UCr. The final estimated model was applied to participants from the School Inner-City Asthma Intervention Study, who submitted urinary samples to the Children's Health Exposure Analysis Resource. Model performance was evaluated using calibration metrics to determine how closely

SUBMITTER: Busgang SA 

PROVIDER: S-EPMC9879698 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature