Effectiveness of a vitamin D regimen in deficient multiple myeloma patients and its effect on peripheral neuropathy.

ABSTRACT:

Purpose

Peripheral neuropathy (PN) is common in multiple myeloma (MM) patients. More insight has been gained concerning the role of vitamin D in preventing PN. However, studies evaluating the effects of vitamin D₃ supplementation on PN are lacking. The aims of this study are to (1) evaluate the effectiveness of a vitamin D₃ regimen on achieving adequate vitamin D levels in deficient MM patients and to (2) exploratively evaluate the effect of vitamin D₃ supplementation on PN.

Methods

Thirty-nine MM patients with inadequate (< 75 nmol/L [= 30 ng/mL]) 25-hydroxyvitamin D (25(OH)D) levels were included in this multicenter, prospective, single-arm study, of whom 35 patients completed the study. They received oral vitamin D₃ for 6 months

SUBMITTER: Oortgiesen BE 

PROVIDER: S-EPMC9879810 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature