Association between iron accumulation in the dorsal striatum and compulsive drinking in alcohol use disorder.

ABSTRACT:

Rationale

Brain iron accumulation has been observed in neuropsychiatric disorders and shown to be related to neurodegeneration.

Objectives

In this study, we used quantitative susceptibility mapping (QSM), an emerging MRI technique developed for quantifying tissue magnetic susceptibility, to examine brain iron accumulation in individuals with alcohol use disorder (AUD) and its relation to compulsive drinking.

Methods

Based on our previous projects, QSM was performed as a secondary analysis with gradient echo sequence images, in 186 individuals with AUD and 274 healthy participants. Whole-brain susceptibility values were calculated with morphology-enabled dipole inversion and referenced to the cerebrospinal fluid. Then, the susceptibility maps were compared between AUD

SUBMITTER: Tan H 

PROVIDER: S-EPMC9879829 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature