Cross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing multiple myeloma.

ABSTRACT: Despite advancements in understanding the pathophysiology of Multiple Myeloma (MM), the cause of rapid progressing disease in a subset of patients is still unclear. MM's progression is facilitated by complex interactions with the surrounding bone marrow (BM) cells, forming a microenvironment that supports tumor growth and drug resistance. Understanding the immune microenvironment is key to identifying factors that promote rapid progression of MM. To accomplish this, we performed a multi-center single-cell RNA sequencing (scRNA-seq) study on 102,207 cells from 48 CD138^- BM samples collected at the time of disease diagnosis from 18 patients with either rapid progressing (progression-free survival (PFS) < 18 months) or non-progressing (PFS > 4 years) disease. Comparative analysis o

SUBMITTER: Pilcher W 

PROVIDER: S-EPMC9879959 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature