Concomitant analyses of intratumoral microbiota and genomic features reveal distinct racial differences in breast cancer.

ABSTRACT: Racial disparities are most accentuated among Black women as their lifetime risk of breast cancer incidence is lower than white and Asian women but their breast cancer related mortality is the highest among all races. Black women are more likely to develop triple-negative breast cancer at a younger age and harbor more aggressive tumors. In addition to tumor-centric alterations, tumor growth is also influenced by multiple other tumor microenvironment-related features, including resident immune cells and microbiota. Hence, in this study, we conduct concurrent genomic and metagenomic analyses, and uncover distinctive intratumoral microbial community compositions and tumor immune microenvironment-related traits in breast tumors from Asian, Black and white women. Interestingly, unique racially

SUBMITTER: Parida S 

PROVIDER: S-EPMC9880005 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature