Role of peptidoglycan recycling enzymes AmpD and AnmK in Acinetobacter baumannii virulence features.

ABSTRACT: Acinetobacter baumannii is an important causative agent of hospital acquired infections. In addition to acquired resistance to many currently-available antibiotics, it is intrinsically resistant to fosfomycin. It has previously been shown that AmpD and AnmK contribute to intrinsic fosfomycin resistance in A. baumannii due to their involvement in the peptidoglycan recycling pathway. However, the role that these two enzymes play in the fitness and virulence of A. baumannii has not been studied. The aim of this study was to characterize several virulence-related phenotypic traits in A. baumannii mutants lacking AmpD and AnmK. Specifically, cell morphology, peptidoglycan thickness, membrane permeability, growth under iron-limiting conditions, fitness, resistance to

SUBMITTER: Tajuelo A 

PROVIDER: S-EPMC9880065 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature