Activity-regulated growth of motoneurons at the neuromuscular junction is mediated by NADPH oxidases.

ABSTRACT: Neurons respond to changes in the levels of activity they experience in a variety of ways, including structural changes at pre- and postsynaptic terminals. An essential plasticity signal required for such activity-regulated structural adjustments are reactive oxygen species (ROS). To identify sources of activity-regulated ROS required for structural plasticity in vivo we used the Drosophila larval neuromuscular junction as a highly tractable experimental model system. For adjustments of presynaptic motor terminals, we found a requirement for both NADPH oxidases, Nox and dual oxidase (Duox), that are encoded in the Drosophila genome. This contrasts with the postsynaptic dendrites from which Nox is excluded. NADPH oxidases generate ROS to the extracellular space. Here, we show that tw

SUBMITTER: Sobrido-Camean D 

PROVIDER: S-EPMC9880070 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature