Cecropin D-derived synthetic peptides in the fight against Candida albicans cell filamentation and biofilm formation.

ABSTRACT: The recent progressive increase in the incidence of invasive fungal infections, especially in immunocompromised patients, makes the search for new therapies crucial in the face of the growing drug resistance of prevalent nosocomial yeast strains. The latest research focuses on the active compounds of natural origin, inhibiting fungal growth, and preventing the formation of fungal biofilms. Antimicrobial peptides are currently the subject of numerous studies concerning effective antifungal therapy. In the present study, the antifungal properties of two synthetic peptides (ΔM3, ΔM4) derived from an insect antimicrobial peptide - cecropin D - were investigated. The fungicidal activity of both compounds was demonstrated against the yeast forms of Candida albicans, Candida tropicalis<

SUBMITTER: Guevara-Lora I 

PROVIDER: S-EPMC9880178 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature