Microbiome and metabolic features of tissues and feces reveal diagnostic biomarkers for colorectal cancer.

ABSTRACT: Microbiome and their metabolites are increasingly being recognized for their role in colorectal cancer (CRC) carcinogenesis. Towards revealing new CRC biomarkers, we compared 16S rRNA gene sequencing and liquid chromatography-mass spectrometry (LC-MS) metabolite analyses in 10 CRC (T_CRC) and normal paired tissues (T_HC) along with 10 matched fecal samples (F_CRC) and 10 healthy controls (F_HC). The highest microbial phyla abundance from T_HC and T_CRC were Firmicutes, while the dominant phyla from F_HC and F_CRC were Bacteroidetes, with 72 different microbial genera identified among four groups. No changes in Chao1 indices were detected between tissues or between fecal samples whereas non-metric multidimension

SUBMITTER: Feng J 

PROVIDER: S-EPMC9880203 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature