Selective stimulation of nociceptive small fibers during intraepidermal electrical stimulation: Experiment and computational analysis.

ABSTRACT: Electrical stimulation of skin nociceptors is gaining attention in pain research and peripheral neuropathy diagnosis. However, the optimal parameters for selective stimulation are still difficult to determine because they require simultaneous characterization of the electrical response of small fibers (Aδ- and C-fibers). In this study, we measured the in vivo electrical threshold responses of small fibers to train-pulse stimulation in humans for the first time. We also examined selective stimulation via a computational model, which combines electrical analysis, and terminal fiber and synaptic models, including the first cutaneous pain C-fiber model. Selective stimulation of small fibers is performed by injecting train-pulse stimulation via coaxial electrodes with an in

SUBMITTER: Niimi Y 

PROVIDER: S-EPMC9880216 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature