Does the VDR gene polymorphism influence the efficacy of denosumab therapy in postmenopausal osteoporosis?

ABSTRACT:

Introduction

One of the challenges of personalized medicine is a departure from traditional pharmacology toward individualized, genotype-based therapies. Postmenopausal osteoporosis is a prevalent condition requiring intensive treatment, whose effects are measurable only after a long time, and the goal is bone fracture prevention. This study aimed to determine the influence of VDR gene variation on anti-osteoporotic one-year treatment with denosumab in 63 Polish women with postmenopausal osteoporosis.

Materials and methods

The correlation between bone mineral density (BMD) of the lumbar vertebral column (L1-L4) and femoral neck, and genotype distributions for the ApaI, BsmI, FokI, and TaqI variants of the VDR gene was analyzed. Bone

SUBMITTER: Wawrzyniak A 

PROVIDER: S-EPMC9880251 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature