Identification of compounds with activity against Trypanosoma cruzi within a collection of synthetic nucleoside analogs.

ABSTRACT:

Introduction

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and it is the most important neglected tropical disease in the Americas. Two drugs are available to treat the infection, but their efficacy in the chronic stage of the disease, when most cases are diagnosed, is reduced. Their tolerability is also hindered by common adverse effects, making the development of safer and efficacious alternatives a pressing need. T. cruzi is unable to synthesize purines de novo, relying on a purine salvage pathway to acquire these from its host, making it an attractive target for the development of new drugs.

Methods

We evaluated the anti-parasitic activity of 23 purine analogs with different substitutions in the complementary chains of their purine r

SUBMITTER: Barnadas-Carceller B 

PROVIDER: S-EPMC9880260 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature