Cuproptosis-related LncRNAs signature as biomarker of prognosis and immune infiltration in pancreatic cancer.

ABSTRACT: Background: Pancreatic cancer (PC) is a malignant gastrointestinal tumor with a terrible prognosis. Cuproptosis is a recently discovered form of cell death. This study is intended to explore the relationship between cuproptosis-related lncRNAs (CRLncs) signature with the prognosis and the tumor microenvironment (TME) of PC. Methods: Transcript sequencing data of PC samples with clinical information were obtained from the Cancer Genome Atlas (TCGA). Univariate Cox regression analysis and LASSO regression analysis were employed to construct the prognostic signature based on CRLncs associated with PC survival. A nomogram was created according to this signature, and the signaling pathway enrichment was analyzed. Subsequently, we explored the link between this prognostic signature

SUBMITTER: Chen H 

PROVIDER: S-EPMC9880288 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature