Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids.

ABSTRACT: End stage renal disease is an increasing problem worldwide driven by aging of the population and increased prevalence of metabolic disorders and cardiovascular disease. Currently, kidney transplantation is the only curative option, but donor organ shortages greatly limit its application. Regenerative medicine has the potential to solve the shortage by using stem cells to grow the desired tissues, like kidney tissue. Immune rejection poses a great threat towards the implementation of stem cell derived tissues and various strategies have been explored to limit the immune response towards these tissues. However, these studies are limited by targeting mainly T cell mediated immune rejection while the rejection process also involves innate and humoral immunity. In this study we investigate whet

SUBMITTER: Gaykema LH 

PROVIDER: S-EPMC9880527 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature