CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction.

ABSTRACT:

Importance

Caffeine is detoxified by cytochrome P450 1A2 (CYP1A2), and genetic variation in CYP1A2 impacts the rate of caffeine clearance. Factors that may modify the association between coffee intake and kidney disease remain unclear.

Objective

To assess whether CYP1A2 genotype modifies the association between coffee intake and kidney dysfunction.

Design, setting, and participants

The Hypertension and Ambulatory Recording Venetia Study (HARVEST) was a prospective cohort study of individuals with stage 1 hypertension in Italy; HARVEST began on April 1, 1990, and follow-up is ongoing. The current study used data from April 1, 1990, to June 30, 2006, with follow-up of approximately 10 years. Blood pressure and biochemical data were collected monthly during the first 3 m

SUBMITTER: Mahdavi S 

PROVIDER: S-EPMC9880799 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature