Towards full clinical trial registration and results publication: longitudinal meta-research study in Northwestern and Central Switzerland.

ABSTRACT:

Objective

The registration of clinical trials is required by law in Switzerland. We investigated (1) the proportion of registered and prospectively registered clinical trials, (2) the availability of results for ethically approved trial protocols, (3) factors associated with increased registration, and (4) reasons for non-registration.

Design and setting

We included all clinical trials with mandatory prospective registration, which were approved by the ethics committee of Northwestern and Central Switzerland between January 1, 2016, and December 31, 2020.

Methods

We extracted relevant trial characteristics from the Swiss Business Administration System for Ethics Committees and systematically searched the International Clinical Trials Registry Platform and primary tria

SUBMITTER: Klatte K 

PROVIDER: S-EPMC9880919 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature