Impact of Computerized Cognitive Training on Default Mode Network Connectivity in Subjects at Risk for Alzheimer's Disease: A 78-week Randomized Controlled Trial.

ABSTRACT:

Background

Mild cognitive impairment (MCI) represents a high risk group for Alzheimer's disease (AD). Computerized Cognitive Games Training (CCT) is an investigational strategy to improve targeted functions in MCI through the modulation of cognitive networks.

Objective

The goal of this study was to examine the effect of CCT versus a non-targeted active brain exercise on functional cognitive networks.

Methods

107 patients with MCI were randomized to CCT or web-based crossword puzzles. Resting-state functional MRI (fMRI) was obtained at baseline and 18 months to evaluate differences in fMRI measured within- and between-network functional connectivity (FC) of the default mode network (DMN) and other large-scale brain networks: the executive control, salience, and sensori

SUBMITTER: Petrella JR 

PROVIDER: S-EPMC9881022 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature