Diencephalic versus Hippocampal Amnesia in Alzheimer's Disease: The Possible Confabulation-Misidentification Phenotype.

ABSTRACT:

Background

Alzheimer's disease (AD) is clinically heterogeneous, including the classical-amnesic (CA-) phenotype and some variants.

Objective

We aim to describe a further presentation we (re)named confabulation-misidentification (CM-) phenotype.

Methods

We performed a retrospective longitudinal case-series study of 17 AD outpatients with the possible CM-phenotype (CM-ADs). Then, in a cross-sectional study, we compared the CM-ADs to a sample of 30 AD patients with the CA-phenotype (CA-ADs). The primary outcome was the frequency of cognitive and behavioral features. Data were analyzed as differences in percentage by non-parametric Chi Square and mean differences by parametric T-test.

Results

Anterograde amnesia (100%) with early confabulation (88.2%), disorientat

SUBMITTER: Abbate C 

PROVIDER: S-EPMC9881034 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature