Computer Aided Drug Design Methodologies with Natural Products in the Drug Research Against Alzheimer's Disease.

ABSTRACT: Natural products are compounds isolated from plants that provide a variety of lead structures for the development of new drugs by the pharmaceutical industry. The interest in these substances increases because of their beneficial effects on human health. Alzheimer's disease (AD) affects occur in about 80% of individuals aged 65 years. AD, the most common cause of dementia in elderly people, is characterized by progressive neurodegenerative alterations, as decrease of cholinergic impulse, increased toxic effects caused by reactive oxygen species and the inflammatory process that the amyloid plaque participates. In silico studies is relevant in the process of drug discovery; through technological advances in the areas of structural characterization of molecules, computational science and mol

SUBMITTER: de Sousa NF 

PROVIDER: S-EPMC9881095 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature