Neurosteroid Modulation of GABAA Receptor Function by Independent Action at Multiple Specific Binding Sites.
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ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC9881108 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Neurosteroid Modulation of GABA<sub>A</sub> Receptor Function by Independent Action at Multiple Specific Binding Sites.
Wang Lei L Covey Douglas F DF Akk Gustav G Evers Alex S AS
Current neuropharmacology 20220101 5
Neurosteroids are endogenous modulators of GABA<sub>A</sub> receptors that mediate anxiety, pain, mood and arousal. The 3-hydroxyl epimers, allopregnanolone (3α-OH) and epiallopregnanolone (3β-OH) are both prevalent in the mammalian brain and produce opposite effects on GABA<sub>A</sub> receptor function, acting as positive and negative allosteric modulators, respectively. This Perspective provides a model to explain the actions of 3α-OH and 3β-OH neurosteroids. The model is based on evidence th ...[more]
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