Pulmonary and physical function limitations in aging men with and without HIV from the Multicenter AIDS Cohort Study (MACS).

ABSTRACT:

Purpose

We examined the associations between pulmonary impairments and physical function and whether age, HIV serostatus, or smoking modified these relationships.

Methods

Using Multicenter AIDS Cohort Study data, we examined associations between pulmonary function (diffusing capacity for carbon monoxide [DL_CO], one-second forced expiratory volume [FEV₁]) and subsequent physical outcomes (gait speed, grip strength, frailty [non-frail, pre-frail, frail]) using mixed models.

Results

Of 1,048 men, 55% were living with HIV, median age was 57(IQR=48,64) and median cumulative pack-years was 1.2(IQR = 0,18.1); 33% and 13% had impaired DL_CO and FEV₁(<80% predicted), respectively. Participants with impaired DL_CO had 3.5 kg

SUBMITTER: Abdo M 

PROVIDER: S-EPMC9881119 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature