Endocrine Functions of Sclerostin.
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ABSTRACT:
SUBMITTER: Riddle RC
PROVIDER: S-EPMC9881182 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Publications
Endocrine Functions of Sclerostin.
Current opinion in endocrine and metabolic research 20230201
Sclerostin, the product of the <i>SOST</i> gene has primarily been studied for its profound impact on bone mass. By interacting with LRP5 and LRP6, the glycoprotein suppresses the propagation of Wnt signals to β-catenin and thereby suppresses new bone formation. In this review, we discuss emerging data which suggest that sclerostin also acts outside the skeleton to influence metabolism. In humans, serum sclerostin levels are associated with body mass index and indices of metabolic function. Like ...[more]
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