Gut microbiome profiles associated with steatosis severity in metabolic associated fatty liver disease.

ABSTRACT:

Aim

The microbiome has been shown to be pivotal in the development of metabolic associated fatty liver disease (MAFLD). Few have examined the relationship of the microbiome specifically with steatosis grade. Therefore, our aim was to characterize the association of the microbiome with MAFLD steatosis severity while adjusting for metabolic comorbidities including diabetes.

Methods

We enrolled patients with MAFLD at the West Los Angeles Veterans Affair Hospital. All patients underwent ultrasound elastography, fasting serum collection, and fecal sampling for 16S sequencing. We examined the associations of microbial diversity and composition with advanced steatosis, defined as a CAP score of ≥ 300 dB/m, with or without the presence of metabolic comorbidities.

Results

Seve

SUBMITTER: Dong TS 

PROVIDER: S-EPMC9881202 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature