Bronchial gene expression alterations associated with radiological bronchiectasis.

ABSTRACT:

Objectives

Discovering airway gene expression alterations associated with radiological bronchiectasis may improve the understanding of the pathobiology of early-stage bronchiectasis.

Methods

Presence of radiological bronchiectasis in 173 individuals without a clinical diagnosis of bronchiectasis was evaluated. Bronchial brushings from these individuals were transcriptomically profiled and analysed. Single-cell deconvolution was performed to estimate changes in cellular landscape that may be associated with early disease progression.

Results

20 participants have widespread radiological bronchiectasis (three or more lobes). Transcriptomic analysis reflects biological processes associated with bronchiectasis including decreased expression of genes involved in cell adhesi

SUBMITTER: Xu K 

PROVIDER: S-EPMC9881226 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature