Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia.

ABSTRACT: Ischemic stroke is a major cause of death and disability worldwide. Translation into the clinical setting of neuroprotective agents showing promising results in pre-clinical studies has systematically failed. One possible explanation is that the animal models used to test neuroprotectants do not properly represent the population affected by stroke, as most of the pre-clinical studies are performed in healthy young male mice. Therefore, we aimed to determine if the response to cerebral ischemia differed depending on age, sex and the presence of comorbidities. Thus, we explored proteomic and transcriptomic changes triggered during the hyperacute phase of cerebral ischemia (by transient intraluminal middle cerebral artery occlusion) in the brain of: (1) young male mice, (2) young female mice,

SUBMITTER: Ramiro L 

PROVIDER: S-EPMC9881265 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature