Depletion of polyfunctional CD26^highCD8⁺ T cells repertoire in chronic lymphocytic leukemia.

ABSTRACT:

Background

CD8⁺ T cells play an essential role against tumors but the role of human CD8⁺CD26⁺ T cell subset against tumors, in particular, haematological cancers such as chronic lymphocytic leukemia (CLL) remains unknown. Although CD4⁺CD26^high T cells are considered for adoptive cancer immunotherapy, the role of CD8⁺CD26⁺ T cells is ill-defined. Therefore, further studies are required to better determine the role of CD8⁺CD26⁺ T cells in solid tumors and haematological cancers.

Methods

We studied 55 CLL and 44 age-sex-matched healthy controls (HCs). The expression of CD26 on different T cell subsets (e.g. naïve, memory, effector, and etc.) was analyzed. Also, functional properti

SUBMITTER: Bozorgmehr N 

PROVIDER: S-EPMC9881277 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature