Integrated investigation of the clinical implications and targeted landscape for RNA methylation modifications in hepatocellular carcinoma.

ABSTRACT:

Background

RNA methylation (RM) is a crucial post-translational modification (PTM) that directs epigenetic regulation. It mostly consists of N¹-methyladenosine (m¹A), 5-methylcytosine (m⁵C), N³-methylcytidine (m³C), N⁶-methyladenosine (m⁶A), and 2'-O-methylation (Nm). The "writers" mainly act as intermediaries between these modifications and associated biological processes. However, little is known about the interactions and potential functions of these RM writers in hepatocellular carcinoma (HCC).

Methods

The expression properties and genetic alterations of 38 RM writers were assessed in HCC samples from five bioinformatic datasets. Two patterns associated with RM writers were identified using cons

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9881284 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature