Invasiveness potential of pneumococcal serotypes in children after introduction of PCV13 in Blantyre, Malawi.

ABSTRACT:

Introduction

The introduction of PCV13 to the Malawi infant immunization schedule in 2011 has been associated with reduced disease from Streptococcus pneumoniae. Improved understanding of serotypes with high invasive potential can guide future vaccination interventions. We aimed to estimate pneumococcal serotypes associated with acute respiratory infection (ARI) and invasive pneumococcal disease (IPD) in hospitalized children in Blantyre, Malawi.

Methods

We analysed data from healthy children under 5 years in the community in Blantyre and children admitted to Queen Elizabeth Central Hospital with ARI between 2015 and 2018. Nasopharyngeal swabs from children were tested for S. pneumoniae and serotyped by latex agglutination if positive. We analysed culture-positive blood and

SUBMITTER: Kirolos A 

PROVIDER: S-EPMC9881369 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature