Application of plasma donor-derived cell free DNA for lung allograft rejection diagnosis in lung transplant recipients.

ABSTRACT:

Background

Donor-derived cell-free DNA (dd-cfDNA) has been applied to monitor acute rejection (AR) in kidney and heart transplantation. This study was aimed to investigate the application of dd-cfDNA levels in the diagnosis of AR and chronic lung allograft dysfunction (CLAD) among the lung transplantation recipients (LTRs).

Methods

One hundred and seventy LTRs were enrolled at the First Affiliated Hospital of Guangzhou Medical University between 1 June 2015 and 30 March 2021. Patients were divided into 4 groups: stable group, AR group, infection group and CLAD group. The level of dd-cfDNA was analyzed using target region sequencing and the performance characteristics of dd-cfDNA for diagnosis of AR and CLAD were determined, respectively.

Results

Kruskal-Wallis test sh

SUBMITTER: Ju C 

PROVIDER: S-EPMC9881379 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature