PLEKHA4 Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Glioma.

ABSTRACT:

Objective

Gliomas are the most common and life-threatening intracranial tumors. Immune infiltration of the tumor microenvironment significantly affects tumor prognosis in glioma. Recently, PLEKHA4 was reported to be upregulated in melanoma and closely associated with tumor genesis and development, but its role in glioma is poorly understood. Our aim was to investigate the expression, functional role, and prognostic value of PLEKHA4 in glioma.

Methods

The expression levels of PLEKHA4 in 33 types of cancer in the TCGA (The Cancer Genome Atlas) database were collected via the UCSC Xena browser. The clinical samples of glioma patients were downloaded from the TCGA database. Immunohistochemistry was used to verify PLEKHA4 expression in tumor tissues. We assessed the influence of

SUBMITTER: Zhang W 

PROVIDER: S-EPMC9881441 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature